TauTology

For some years, I've followed various One Drug Ponies in the Alzheimer's race. Most continue to play the Aβ line (and continue to fail, even the Big Guys), but even these, every now and again, would make passing reference to their One Drug's effect on tau proteins. Without much data or specifics.

Today comes another Derek Lowe piece on recent publications around tau in general CNS problems. Here's the punch line:

The capillaries back there are a different and more permissive population than the usual ones in the central nervous system (and thus the rapid onset of snorted drugs of abuse as well). The paper shows a single dose of this antibody in the mouse model reducing the amount of pathological tau and increasing cognitive function in the mice. Which is quite startling - you might have expected to have to go through a longer course of treatment to see something significant.

That's one hell of a punch line. I said that, yes I did. Could be a lot of moolah wasted on the Aβ sink.

Looking at the authors of the various papers, didn't see any known AD companies. Yet.