29 November 2021

About That Pill

Not behind a paywall (they've said all Covid reporting wouldn't be, but some has been), STAT has reporting on the latest data on Merck's anti-viral, molnupiravir, which indicates lower effectiveness than initial reports.

Curiously, not this nor any of the other reports on mab's and anti-viral's I've seen (which doesn't mean all) discuss the effect on transmission by these 'alternatives' to vaccination. Moreover, the Merck pill must be started within 3 to 5 days from symptoms. We know that Covid-Δ (and Covid-Ο is worse based on initial data) is transmissible during that time, and for much longer for the asymps. We know, fur shur, that transmission of all Covid is driven (largely?) by the asymp population. We should be paying much attention, through aggressive testing; but that's another episode. What happens if Covid-Ο has at least Covid-Δ's asymp precentage and Covid-Β's lethality?? Can we say "Ta ta" to the Red States deniers? One can only hope. From one perspective, accepting that free-loading by the deniers is just OK, this is the worst-case scenario.

IOW, the Covid Morons are hanging their hats on clearly sub-optimal drugs. And, moreover, this is yet another variant to come from a wannaBePresident Huey Long 2024-ian Shithole Country, Beta being much earlier. It turned out that Covid-Δ out Darwin-ed Beta, and this fact was praised as a Good Thing, relatively speaking, because Beta is much worse.
The Beta variant was at the top of people's concerns at the beginning of the year because it was the best at escaping the immune system. But in the end it was the faster-spreading Delta that took over the world.
And, it turns out, based on current data, that Covid-Ο bears mutations with Beta. That is not Good Eats.
"The recently described Omicron variant includes mutations seen in the Delta variant that are believed to increase transmissibility and mutations seen in the Beta and Delta variants that are believed to promote immune escape. The combination of mutations represents a significant potential risk to accelerate the waning of natural and vaccine-induced immunity," Moderna said Friday in a news release.
I told y'all it was coming. Now, one possible future is that Covid-Ο does a Covid-Α, invading Canada and only (mostly) Michigan. Michigan isn't handling Covid-Δ all that well, but then most of the Cold States aren't either. Do you expect Covid-Δ to trundle South this winter??? Does a bear shit in the woods? The sunnier scenario is that the Delta mutations dominate, rather than the Beta, and Covid-Ο is kept in check by existing vaccines. That won't help the Red States, of course. But, at this point in the proceedings, Fuck Them. Die motherfuckers!!!

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