I agree, in very large measure, with Janert: the biggest bang for the quant buck is to focus on the obvious. I don't recall him being quite that blunt, but you get the point.
ASCO is this weekend, and Feuerstein tweets a link to this post. I'll not show any of it, as I really want you to see the graph he shows. I will mention that he uses my favorite word, thanks Groucho, in describing pharma investing. And, one might add, Great Recession investing: "lemming".